Note that the microbiologists definition of a chemotherapeutic agent requires that the. Antihypertensive drugs are often given in combination because some of the side effects. Chemotherapeutics definition of chemotherapeutics by. It includes alkylating agents, antimetabolites, antitumor antibiotics, anthracyclines, topoisomerase inhibitors, etc. The treatment of a disease with a chemical substance is called chemotherapy and the chemical substance used for the purpose is known as a chemotherapeutic. Definition of chemotherapy nci dictionary of cancer. Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the proliferation of rapidly growing. Antimicrobial, antiparasitic, and antineoplastic chemotherapeutic agents are distinguished.
With the direct placement of the drug in the periodontal pocket, the chance of drug resistance is. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Chemotherapeutic definition of chemotherapeutic by the free. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Pdf antibiotics and chemotherapeutic agents researchgate. Chemotherapy is a type of cancer treatment that uses one or more anticancer drugs chemotherapeutic agents as part of a standardized chemotherapy.
Classification of anticancer drugs based on their differential impacts on dcs. Chemotherapy may be given with a curative intent which almost always involves combinations of drugs, or it may aim to prolong life. Chapter 3 principles of chemotherapy ray page, do, phd, and chris takimoto, md, phd the effective use of cancer chemotherapy requires an understanding of the principles of tumor biology, cellular kinetics, pharmacology, and drug resistance. Treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Definition of chemotherapeutic agent in the definitions. General characteristics of chemotherapeutic agents 3. This teacherdeveloped 5th grade word list covers all the basics to prepare students for middle school. Each drug is listed once at present, though it might fall in more than one subsection. Cancer chemotherapeutic agents are often given in combination because cellular interactions such as inhibiting cell replication and promoting apoptosis among the drugs cause more cancer cell death. Get a printable copy pdf file of the complete article 1. This is a list of chemotherapeutic agents, also known as cytotoxic agents, that are known to be of use in chemotherapy for cancer. In order to understand how these medications work, we need to understand a bit about tumor cells. Toxicity of chemotherapeutic agents to normal cells is the cause of unpleasant side effects. Drugs or biologicals and cancer chemotherapeutic agents approved for marketing by the food and drug administration fda are considered safe and effective for purposes of this requirement when used for indications specified on the labeling.
The medical treatment of extravasation is based on proper maintenance of the intravenous iv line and application of cold or warm compresses, plus the use of antidotes when available. Definition of nonchemotherapeutic in the definitions. The local delivery of controlled release antimicrobials provides a means of professionally administering chemotherapeutic agents directly into the periodontal pocket in order to provide slow release of the drug. Some types of cancer can be treated with just chemotherapy. Chemotherapeutic agents stateautocollapse shows the template collapsed to the title bar if there is a navbar, a sidebar, or some other table on the page with the collapsible attribute. Chemotherapy agent an overview sciencedirect topics. Sep, 2017 the adverse health effects associated with antineoplastic agents cancer chemotherapy drugs, cytotoxic drugs in cancer patients and some noncancer patients treated with these drugs are well documented. Pdf the ideal antimicrobial agent should he nontoxic to the host selective toxicity, nonallergenic, soluble in body fluids, able to be maintained. Therefore, payment may be made for an fda approved drug or biological or cancer chemotherapeutic agent if. Chemotherapeutic agent synonyms, chemotherapeutic agent pronunciation, chemotherapeutic agent translation, english dictionary definition of chemotherapeutic agent. It is usually used to refer to antineoplastic drugs. Chemotherapy definition is the therapeutic use of chemical agents to treat disease. Pdf classification of chemotherapeutic agents based on their.
The treatment of cancer using specific chemical agents or drugs that are selectively destructive to malignant cells and tissues. Chemotherapy may be given with a curative intent which almost always involves combinations of drugs, or it may aim to prolong life or to reduce symptoms palliative chemotherapy. Most chemotherapeutic agents can cause varying degrees of local tissue injuries when extravasated. Chemotherapy definition of chemotherapy by merriamwebster. Chemotherapy may be given by mouth, injection, or infusion, or on the skin, depending on the type and stage of the cancer being treated. Chapter 12 chemotherapeutic agents flashcards quizlet.
Chemotherapeutic agent definition of chemotherapeutic. Since chemotherapeutic drugs cannot distinguish between normal cells and cancer cells, both types of cells are affected by chemotherapy. Medication errors in administration of chemotherapeutic agents. Nov 22, 2012 cancer is a disease in which there is uncontrolled multiplication and spread within the body of abnormal forms of bodys own cells. Chemotherapeutic agents stateexpanded to show the template expanded, i. Classification of chemotherapeutic agents based on their differential. By contrast, an antibiotic is a product of the metabolism of a microorganism. Once again, we employed the same dual criteria to define a.
Chemotherapeutic agent legal definition of chemotherapeutic agent. Chemotherapeutic agents list of high impact articles ppts. Microbial pathogens grow on and within the body of other living beings and their colonization may lead to disease, disability, and death. Several novel chemotherapeutics that target specific signaling pathways are now. The term generally implies a chemical that has been synthesized by chemists or produced by a modification of a preexisting chemical.
Drugs with different patterns of resistance should be combined to minimize crossresistance. Chapter 10 antibiotics and chemotherapeutic agents. Anthracyclines are very efficient chemotherapeutic agents, derivatives of streptomyces peucetius which is a pigment producing bacteria. Other articles where chemotherapeutic agent is discussed. Chemotherapeutic agent article about chemotherapeutic agent. Ongoing treatment strategies include combining chemotherapy with targeted molecular therapeutic agents, antiangiogenic treatments, and biologicals. Hazardous waste has specific management requirements for marking, labeling, time limits for storing, transportation, disposal methods and recordkeeping. However, the value of chemotherapy lies in the fact that the killing effect of chemotherapeutic agents has a. Tumors are made up of cells that are reproducing at abnormally high rates. Pdf classification of chemotherapeutic agents based on. An agent used to treat cancer administered in regimens of one or more cycles, combining two or more agents over a period of days to weeks. Chemotherapy is used to describe medications that treat cancer. Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells article pdf available in cancer research 6917.
Chemotherapeutic agents knowledge for medical students and. Here we report differential impacts of 54 anticancer drugs on dc. Pdf despite the crucial roles dendritic cells dc play in host immunity against. Chemotherapeutic agents include substances of natural origin for example, antibiotics and synthetic preparations for example, sulfanilamides, nitrofurans, and paraaminosalicylic acid.
Some are cytotoxic, meaning that the drugs damage the cells and prevent them from replicating or increasing in number. Full text full text is available as a scanned copy of the original print version. Containers that held hazardous waste chemotherapy drugs, and do not meet the definition of empty, are hazardous waste when discarded. Chemotherapeutic agents definitions flashcards quizlet. Among 271 fetuses exposed to chemotherapeutic agents during the first trimester, 19. Chemotherapy often abbreviated to chemo and sometimes ctx or ctx is a type of cancer treatment that uses one or more anticancer drugs chemotherapeutic agents as part of a standardized chemotherapy regimen. They are classified according to their mechanism of action and include alkylating agents, antimetabolites, topoisomerase inhibitors, and mitotic inhibitors. Terminology used in describing chemotherapy chemotherapy is administered with a variety of treatment schedules designed according to the intent and responsiveness of therapy. Local coverage article for approved drugs and biologicals.
It uses special drugs to kill cancer cells in the body. Chemotherapeutic agents and their applications balaji college of pharmacy mr. The ideal antimicrobial agent should he nontoxic to. Chemotherapeutic agent definition of chemotherapeutic agent. Chemotherapeutic definition is of, relating to, or used in chemotherapy. The very nature of antineoplastic agents make them harmful to healthy cells and tissues as well as the cancerous cells. Both the size and distribution of charge of the sulfonamides and paba molecule are very similar, so sulfa drug play a role of metabolism antagonist. Control of microbial growth online textbook of bacteriology.
How chemotherapy drugs work american cancer society. Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the proliferation of rapidly growing cells, typically in the context of malignancy. Information and translations of nonchemotherapeutic in the most comprehensive dictionary definitions resource on the web. Thanks to the development of new, effective chemotherapeutic agents. This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. More than 100 chemotherapy or chemo drugs are used to treat cancer either alone or in combination with other drugs or treatments. Chemotherapeutic article about chemotherapeutic by the free. New chemotherapeutic agents with more specificity, less toxicity, and the improved ability to halt molecular pathways of tumorigenesis are being developed and need to be optimized. Chemotherapeutic agents definitions learn with flashcards, games, and more for free. Chemotherapeutic agents knowledge for medical students. Chapter 9 chemotherapeutic agents 02 authorstream presentation.
Chemotherapeutic agents are chemical substances used within the body for therapeutic purposes. Medication errors in administration of chemotherapeutic. Such agents are toxic to cells with high proliferative ratese. Predisposing factors for laryngeal candidiasis include immunodeficiency syndromes, immunosuppressive medications e. Chemotherapeutic agents and their applications authorstream. These drugs are very different in their chemical composition, how they are taken, their usefulness in treating specific forms of cancer, and their side effects. Nov, 2014 chemotherapeutic agents and their applications. Chemotherapeutic agents should be handled according to the a. Chemotherapeutics definition of chemotherapeutics at. The basics what is chemotherapy and how does it work. Still, significant challenges remain for specific cancer types, such as glioblastoma, in which a combination of early detection, surgery, chemotherapy, and radiotherapy cannot extend survival beyond 12 years. They are classified according to their mechanism of action and include alkylating agents, antimetabolites, topoisomerase inhibitors, and mitotic.